Behandlung von Opioidsucht - Eine Übersicht
Behandlung von Opioidsucht - Eine Übersicht
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Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient hinein methadone hydrochloride tablets.
The initial methadone dose should be carefully titrated to the individual. Too rapid titration for the patient's sensitivity is more likely to produce adverse effects.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result hinein death. Patients and caregivers should be instructed to keep methadone in a secure place out of the reach of children and to discard unused methadone in such a way that individuals other than the patient for whom it welches originally prescribed will not come in contact with the drug.
Methadone can be abused in a manner similar to other opioid agonists, legal or illicit. This should Beryllium considered when prescribing or dispensing methadone hydrochloride tablets hinein situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.
Some heartbeat problems have happened rein people using smaller doses of methadone hydrochloride tablets for treatment of narcotic drug addiction.
When starting treatment with methadone hydrochloride tablets for narcotic drug dependence, you should be aware that your dose of methadone will “hold” for longer periods of time as treatment goes on.
Additional information on the potential risks of methadone may be derived from animal data. Methadone does not appear to be teratogenic in the rat or rabbit models. However, following large doses, methadone produced teratogenic effects in the guinea pig, hamster and mouse. One published study in pregnant hamsters indicated that a single subcutaneous dose of methadone ranging from 31 to 185 Magnesium/kg (the 31 Magnesium/kg dose is approximately 2 times a human daily oral dose of 120 mg/day on a mg/m2 Stützpunkt) on day 8 of gestation resulted in a decrease in the number of fetuses durch litter and an increase hinein the percentage of fetuses exhibiting congenital malformations described as exencephaly, cranioschisis, and “various other lesions”.
Methadone differs from many other opioid agonists rein several important ways. Methadone's pharmacokinetic properties, coupled with high interpatient variability in its absorption, metabolism, and relative analgesic potency, necessitate a cautious and highly individualized approach to prescribing. Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration. While methadone's duration of analgesic action (typically 4 to 8 hours) hinein the Schauplatz of single-dose studies approximates that of morphine, methadone's plasma elimination half-life is substantially longer than that of morphine (typically 8 to 59 hours vs.
Extreme caution is necessary when any drug known to have the potential to prolong the QT interval is prescribed in conjunction with methadone.
The severity of this syndrome will depend on the degree of physical dependence and the dose of the antagonist administered. If antagonists must Beryllium used to treat serious respiratory depression in the physically dependent patient, the antagonist should Beryllium administered with extreme care and by titration with smaller than usual doses of the antagonist.
for maintenance treatment of narcotic drug addiction along with other social and medical services. Stopping maintenance treatment of narcotic drug addiction with methadone hydrochloride tablets may result in a return Methadontabletten 10 mg online to narcotic drug use.
Physicians should individualize treatment in every case (Weiher DOSAGE AND ADMINISTRATION), taking into account the high degree of interpatient variability hinein response to and metabolism of methadone.
Dosage adjustment using higher doses or administering the daily dose hinein divided doses may be necessary rein pregnant women treated with methadone (Teich CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
Initial doses should not be determined by previous treatment episodes or dollars spent vermittels day on illicit drug use.